For the research project BRIDGE “Exploring Bioactivity of Natural Compounds: From Encapsulation Strategies to Drug Discovery for Biomedical Targets", funded by Research Südtirol (call 2024), CUP H33C26000290005, the working group “Laboratory of NMR Spectroscopy” at Laimburg Research Centre is looking for:

1 scientific collaborator (f/m/d)

code BR.26-NMR-02.22

The project aims to identify, characterize, and optimize bioactive compounds derived from apple and grape by-products, as well as elucidate their molecular mechanisms of action against protein aggregation associated with neurodegenerative diseases. 

The areas of responsibility are as follows:

• Expression, purification, and characterization of recombinant amyloidogenic proteins
• Development and application of NMR methods to study protein aggregation and protein–ligand interactions
• Screening of natural extracts, purified compounds, and encapsulated formulations as aggregation inhibitors using NMR spectroscopy and LC-MS
• Investigation of the molecular mechanisms underlying inhibition of amyloid formation
• Analysis of aggregation kinetics and biophysical data
• Preparation of scientific reports, publications, and presentations
• Collaboration with project partners in natural product chemistry, encapsulation technologies, and computational drug discovery

• Completed university studies of at least three years attested by a diploma in chemistry, biotechnology, natural sciences or similar
• Good knowledge of Italian or German (C1 level) language - to be evaluated during the interview
• Good knowledge of English (B2 level) - to be evaluated during the interview.